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TIMES

[11.08.2017] Insufficiency has been identified in simulated S9 metabolism of specific terpenoid chemicals. The limitation could be fixed by the corrected version of the Rat liver S9 metabolism transformation table. The correction requires:

1. Download the TimesMetabolismFix.zip package and extract its contents to use them in the next steps

2. Paste the modified transformation table - S9_Rodent_Ames_10.08.17.txt file (common for three TIMES models - AMES with S9, CA with S9 and MLA with S9) in the following installation folders (default directories):

   a) C:\Program Files (x86)\Common Files\OASIS-LMC\TIMES 2.28.1\data\Metabo models\Ames S9 activated
   b) C:\Program Files (x86)\Common Files\OASIS-LMC\TIMES 2.28.1\data\Metabo models\Chromosomal Aberrations S9 activated
   c) C:\Program Files (x86)\Common Files\OASIS-LMC\TIMES 2.28.1\data\Metabo models\Mouse lymphoma S9 activated

3. Replace the configuration files of the three models (AMES with S9, CA with S9 and MLA with S9) with the new ones as follows:

   a) Ames S9 activated.modelconfig.ini should be replaced with the new one in the following directory: C:\Program Files (x86)\Common Files\OASIS-LMC\TIMES 2.28.1\data\Metabo models\Ames S9 activated

   b) Chromosomal Aberrations S9 activated.modelconfig.ini should be replaced with the new one in the following directory: C:\Program Files (x86)\Common Files\OASIS-LMC\TIMES 2.28.1\data\Metabo models\Chromosomal Aberrations S9 activated

   c) Mouse Lymphoma_S9_activated.modelconfig.ini should be replaced with the new one in the following directory: C:\Program Files (x86)\Common Files\OASIS-LMC\TIMES 2.28.1\data\Metabo models\Mouse lymphoma S9 activated

Once the new files are in the correct directories TIMES needs to be restarted.