Human Health Models

 

Q. Which Salmonella strains are included in building the Ames mutagenicity model?


A. Given the high correlation between the experimental values of the different Salmonella strains for the training set chemicals the TIMES methodology was applied to predict mutagenicity based on data for any of the Ames tester strains.

 

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Q: What kind of results are provided by TIMES Ames mutagenicity model?

 

A: The model provides prediction results for the chemicals as parent structures and also predictions for all generated metabolites. The generated metabolic tree can be visually analizyed and in case of positive prediction supporting information of the interaction mechanism is provided.